Hot Paper - Coulomb attraction driven spontaneous molecule-hotspot paring enables universal, fast, and large-scale uniform single-molecule Raman spectroscopy

Coulomb attraction driven spontaneous molecule-hotspot paring enables universal, fast, and large-scale uniform single-molecule Raman spectroscopy

库仑引力驱动的自发分子-热点配对实现了通用、快速且大规模均匀的单分子拉曼光谱分析
クーロン引力に駆り立てられた自発的な分子-ホットスポットペアリングは、普遍的で高速かつ大規模な均一な単分子ラマン分光法を実現する
쿨롱 인력에 의해 구동되는 자발적인 분자-핫스팟 짝짓기는 보편적이고 빠르며 대규모로 균일한 단일 분자 라만 분광학을 가능하게 한다
La atracción de Coulomb impulsa el emparejamiento espontáneo de moléculas con puntos calientes, permitiendo espectroscopía Raman de moléculas individuales universal, rápida y a gran escala
L'attraction de Coulomb permet une association spontanée des molécules avec les points chauds, facilitant une spectroscopie Raman uniforme, universelle, rapide et à grande échelle pour les molécules individuelles
Кулоновское притяжение, обусловливающее спонтанное сопряжение молекул с горячими точками, позволяет осуществлять универсальный, быстрый и масштабируемый однородный рамановский спектроскопический анализ отдельных молекул

Lihong Hong 洪丽红 ¹ ², Haiyao Yang 杨海遥 ¹, Jianzhi Zhang 张简智 ¹, Zihan Gao 高子涵 ¹, Zhi-Yuan Li 李志远 ¹ ³

¹ School of Physics and Optoelectronics, South China University of Technology, Guangzhou 510640, China
中国广州华南理工大学物理与光电学院
² Institute of Physics, Henan Academy of Sciences, Zhengzhou 450046, China
中国郑州河南省科学院物理研究所
³ State Key Laboratory of Luminescent Materials and Devices, South China University of Technology, Guangzhou 510640, China
中国广州华南理工大学发光材料与器件国家重点实验室

https://doi.org/10.29026/oea.2025.240309

https://www.oejournal.org/oea/article/doi/10.29026/oea.2025.240309

Opto-Electronic Advances, 17 July 2025

Abstract

Raman spectroscopy offers a great power to detect, analyze and identify molecules, and monitor their temporal dynamics and evolution when combined with single-molecule surface-enhanced Raman scattering (SM-SERS) substrates. Here we present a SM-SERS scheme that involves simultaneously giant chemical enhancement from WS2 2D materials, giant electromagnetic enhancement from plasmonic nanogap hot spot, and inhibition of molecular fluorescence influence under near-infrared laser illumination.

Remarkably we find Coulomb attraction between analyte and gold nanoparticle can trigger spontaneous formation of molecule-hotspot pairing with high precision, stability and robustness. The scheme has enabled realization of universal, robust, fast, and large-scale uniform SM-SERS detection for three Raman molecules of rhodamine B, rhodamine 6G, and crystal violet with a very low detection limit of 10−16 M and at a very fast spectrum acquisition time of 50 ms.

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