Hot Paper - Novel all-fiber-optic technology for control and multi-color probing of neural circuits in freely-moving animals

Novel all-fiber-optic technology for control and multi-color probing of neural circuits in freely-moving animals

用于控制和多色探测自由运动动物神经回路的新型全光纤技术
自由運動動物の神経回路を制御し多色探査するための新しい全光ファイバ技術
자유운동동물의 신경회로를 제어하고 다색적으로 탐지하는 새로운 전광섬유기술
Nueva tecnología de fibra óptica completa para controlar y detectar multicolor los circuitos neuronales de los animales en movimiento libre
Nouvelle technologie tout fibre pour le contrôle et la détection multicolore des circuits neuronaux d'animaux en mouvement libre
Новые полностью волоконно - оптические технологии для управления и многоцветного обнаружения нейронных цепей у свободно движущихся животных

Xingde Li 李兴德

Department of Biomedical Engineering, Johns Hopkins University, Baltimore, MD 21205, USA

https://doi.org/10.29026/oea.2023.230086

https://www.oejournal.org/article/doi/10.29026/oea.2023.230086

Opto-Electronic Advances, 20 July 2023

Abstract

All-fiber-optic photometry system based on a multi-branch fiber bundle has achieved, for the first time, simultaneous optogenetic manipulation and dual-color recording of neuronal Ca2+ or neurotransmitter signals in freely moving animals, providing a powerful tool for comprehensive analysis of neural circuit function and the study of neurological diseases.

Reviews and Discussions