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Protective effects on acute hypoxic-ischemic brain damage in mfat-1 transgenic mice by alleviating neuroinflammation
减轻神经炎症对mfat-1转基因小鼠急性缺氧缺血性脑损伤的保护作用
神経炎症を軽減することによるmfat-1トランスジェニックマウスの急性低酸素性虚血性脳損傷に対する保護効果
신경 염증을 완화하여 mfat-1 형질 전환 마우스의 급성 저산소 - 허혈성 뇌 손상에 대한 보호 효과
Efectos protectores sobre el daño cerebral hipóxico-isquémico agudo en ratones transgénicos mfat-1 al aliviar la neuroinflamación
Effets protecteurs sur les lésions cérébrales hypoxiques-ischémiques aiguës chez les souris transgéniques mfat-1 en atténuant la neuroinflammation
Защитные эффекты при остром гипоксически-ишемическом повреждении головного мозга у трансгенных мышей mfat-1 путем облегчения нейровоспаления
Geng Xue 耿雪 ¹, Wang Meng 王蒙 ¹, Leng Yunjun 冷允俊 ¹, Li Lin 李琳 ¹, Yang Haiyuan 杨海元 ¹ ², Dai Yifan 戴一凡 ¹ ², Wang Ying 王盈 ¹ ²
¹ Jiangsu Key Laboratory of Xenotransplantation, Nanjing Medical University, Nanjing, Jiangsu 211166, China
中国 江苏 南京 南京医科大学 江苏省异种移植重点实验室
² Key Laboratory of Targeted Intervention of Cardiovascular Disease, Collaborative Innovation Center for Cardiovascular Disease Translational Medicine, Nanjing Medical University. Nanjing, Jiangsu 211166, China
中国 江苏 南京 南京医科大学 心血管病转化医学协同创新中心 心血管病分子干预重点实验室
The Journal of Biomedical Research, 30 September 2021
Abstract

Acute hypoxic-ischemic brain damage (HIBD) mainly occurs in adults as a result of perioperative cardiac arrest and asphyxia. The benefits of n-3 polyunsaturated fatty acids (n-3 PUFAs) in maintaining brain growth and development are well documented. However, possible protective targets and underlying mechanisms of mfat-1 mice on HIBD require further investigation.

The mfat-1 transgenic mice exhibited protective effects on HIBD, as indicated by reduced infarct range and improved neurobehavioral defects. RNA-seq analysis showed that multiple pathways and targets were involved in this process, with the anti-inflammatory pathway as the most significant. This study has shown for the first time that mfat-1 has protective effects on HIBD in mice.

Activation of a G protein-coupled receptor 120 (GPR120)-related anti-inflammatory pathway may be associated with perioperative and postoperative complications, thus innovating clinical intervention strategy may potentially benefit patients with HIBD.
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