Tip-enhanced Raman scattering of glucose molecules
葡萄糖分子的尖端增强拉曼散射
グルコース分子の尖強化ラマン散射
포도당 분자의 팁 강화 라만 산란
Dispersión Raman de moléculas de glucosa mejorada por la punta
Diffusion Raman exaltée par la pointe des molécules de glucose
Раманское рассеяние молекул глюкозы с усилением конца
Zhonglin Xie ¹, Chao Meng ¹, Donghua Yue ¹, Lei Xu ³, Ting Mei ¹, Wending Zhang ¹ ²
¹ Key Laboratory of Light Field Manipulation and Information Acquisition, Ministry of Industry and Information Technology, School of Physical Science and Technology, Northwestern Polytechnical University, Xi'an 710129, China
中国 西安 西北工业大学物理科学与技术学院 光场调控与信息感知工业和信息化部重点实验室
² Research & Development Institute of Northwestern Polytechnical University in Shenzhen, Shenzhen 518063, China
中国 深圳 西北工业大学深圳研究院
³ Advanced Optics & Photonics Laboratory, Department of Engineering, School of Science & Technology, Nottingham Trent University, Nottingham NG11 8NS, United Kingdom
Glucose molecules are of great significance being one of the most important molecules in metabolic chain. However, due to the small Raman scattering cross-section and weak/non-adsorption on bare metals, accurately obtaining their "fingerprint information" remains a huge obstacle. Herein, we developed a tip-enhanced Raman scattering (TERS) technique to address this challenge.
Adopting an optical fiber radial vector mode internally illuminates the plasmonic fiber tip to effectively suppress the background noise while generating a strong electric-field enhanced tip hotspot. Furthermore, the tip hotspot approaching the glucose molecules was manipulated via the shear-force feedback to provide more freedom for selecting substrates.
Consequently, our TERS technique achieves the visualization of all Raman modes of glucose molecules within spectral window of 400–3200 cm−1, which is not achievable through the far-field/surface-enhanced Raman, or the existing TERS techniques. Our TERS technique offers a powerful tool for accurately identifying Raman scattering of molecules, paving the way for biomolecular analysis.
