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NIR-triggered on-site NO/ROS/RNS nanoreactor: Cascade-amplified photodynamic/photothermal therapy with local and systemic immune responses activation
NIR触发的现场NO/ROS/RNS纳米反应器:具有局部和全身免疫反应激活的级联放大光动力/光热疗法
NIRによって触発される現場NO/ROS/RNSナノ反応器:局所的及び全身免疫反応活性を有するカスケード増幅光動力/光熱療法
NIR이 트리거하는 현장 NO/ROS/RNS 나노 반응기: 국소 및 전신 면역 반응 활성화를 갖춘 급연 증폭 광동력/광열 요법
Nanoreactor in situ no / ROS / RNS activado por nir: Fototerapia Fotodinámica / fototérmica en cascada con activación de la respuesta inmune local y sistémica
Nanoréacteurs in situ no / Ros / Rns déclenchés par NIR: thérapie photodynamique / photothermique amplifiée en cascade avec activation de la réponse immunitaire locale et systémique
Полевой нанореактор NO / ROS / RNS, работающий на NIR: каскадная радиодинамическая / фототермальная терапия с активацией локального и общего иммунного ответа
Ziqing Xu ¹, Yakun Kang ², Jie Zhang ¹, Jiajia Tang ¹, Hanyao Sun ¹, Yang Li ¹, Doudou He ¹, Xuan Sha ¹, Yuxia Tang ¹, Ziyi Fu ³, Feiyun Wu ¹, Shouju Wang ¹
¹ Laboratory of Molecular Imaging, Department of Radiology, The First Affiliated Hospital of Nanjing Medical University, Nanjing 210029, China
中国 南京 南京医科大学第一附属医院放射科 分子影像实验室
² Department of Breast Surgery, The First Affiliated Hospital of Nanjing Medical University, Nanjing 210029, China
中国 南京 南京医科大学第一附属医院乳腺病科
³ Department of Women & Children Research Center, The First Affiliated Hospital, Nanjing Medical University, Nanjing 210029, China
中国 南京 南京医科大学附属第一医院妇幼研究中心
Opto-Electronic Advances, 5 June 2024
Abstract

Photothermal and photodynamic therapies (PTT/PDT) hold promise for localized tumor treatment, yet their full potential is hampered by limitations such as the hypoxic tumor microenvironment and inadequate systemic immune activation. Addressing these challenges, we present a novel near-infrared (NIR)-triggered RNS nanoreactor (PBNO-Ce6) to amplify the photodynamic and photothermal therapy efficacy against triple-negative breast cancer (TNBC).

The designed PBNO-Ce6 combines sodium nitroprusside-doped Prussian Blue nanoparticles with Chlorin e6 to enable on-site RNS production through NIR-induced concurrent NO release and ROS generation. This not only enhances tumor cell eradication but also potentiates local and systemic antitumor immune responses, protecting mice from tumor rechallenge. Our in vivo evaluations revealed that treatment with PBNO-Ce6 leads to a remarkable 2.7-fold increase in cytotoxic T lymphocytes and a 62% decrease in regulatory T cells in comparison to the control PB-Ce6 (Prussian Blue nanoparticles loaded with Chlorin e6), marking a substantial improvement over traditional PTT/PDT.

As such, the PBNO-Ce6 nanoreactor represents a transformative approach for improving outcomes in TNBC and potentially other malignancies affected by similar barriers.
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