Pencil-beam scanning catheter for intracoronary optical coherence tomography
用于冠状动脉内光学相干断层扫描的铅笔束扫描导管
冠状動脈内光コヒーレンストモグラフィー用のペンシルビームスキャニングカテーテル
관내 광간섭 단층 촬영을 위한 연필 빔 스캐닝 카테터
Catéter de escaneo de haz de lápiz para tomografía de coherencia óptica intracoronaria
Cathéter à faisceau crayon pour tomographie par cohérence optique intracoronaire
Карандашно-лучевой сканирующий катетер для интракоронарной оптической когерентной томографии
Jiqiang Kang 康吉强 ¹, Rui Zhu 朱锐 ² ³ ⁴, Yunxu Sun 孙云旭 ¹, Jianan Li 李嘉男 ³ ⁴, Kenneth K. Y. Wong 黄建业 ⁵ ⁶
¹ School of Electronic and Information Engineering, Harbin Institute of Technology (Shenzhen), Shenzhen 518055, China
中国 深圳 哈尔滨工业大学（深圳）电子与信息工程学院
² International Graduate School at Shenzhen, Tsinghua University, Shenzhen 518055, China
中国 深圳 清华大学深圳国际研究生院
³ Shenzhen Vivolight Medical Device & Technology Co., Ltd., Shenzhen 518055, China
中国 深圳 深圳市中科微光医疗器械技术有限公司
⁴ State Key Laboratory of Transient Optics and Photonics, Xi’an Institute of Optics and Precision Mechanics, Chinese Academy of Sciences, Xi'an 710119, China
中国 西安 中国科学院西安光学精密机械研究所 瞬态光学与光子技术国家重点实验室
⁵ Department of Electrical and Electronic Engineering, The University of Hong Kong, Pokfulam Road, Hong Kong, China
中国 香港 香港大学电机电子工程系
⁶ Advanced Biomedical Instrumentation Centre, Hong Kong Science Park, Shatin, New Territories, Hong Kong, China
中国 香港 香港科学园 先进生物医学仪器中心
Current gradient-index (GRIN) lens based proximal-driven intracoronary optical coherence tomography (ICOCT) probes consist of a spacer and a GRIN lens with large gradient constant. This design provides great flexibility to control beam profiles, but the spacer length should be well controlled to obtain desired beam profiles and thus it sets an obstacle in mass catheter fabrication. Besides, although GRIN lens with large gradient constant can provide tight focus spot, it has short depth of focus and fast-expanded beam which leads to poor lateral resolution for deep tissue.
In this paper, a type of spacer-removed probe is demonstrated with a small gradient constant GRIN lens. This design simplifies the fabrication process and is suitable for mass production. The output beam of the catheter is a narrow nearly collimated light beam, referred to as pencil beam here. The full width at half maximum beam size varies from 35.1 µm to 75.3 µm in air over 3-mm range.
Probe design principles are elaborated with probe/catheter fabrication and performance test. The in vivo imaging of the catheter was verified by a clinical ICOCT system. Those results prove that this novel pencil-beam scanning catheter is potentially a good choice for ICOCT systems.
