궤양성 대장염의 괴저성 농피
Pioderma gangrenoso en la colitis ulcerosa
Pyoderma gangrenosum dans la rectocolite hémorragique
Гангренозная пиодермия при язвенном колите
Meng-You Zeng ¹ ², Wei Liu 刘伟 ¹ ²
¹ Institute of Digestive Disease, China Three Gorges University, Yichang 443000, China
中国 宜昌 三峡大学消化疾病研究所
² Department of Gastroenterology of Yichang Central People's Hospital, Yichang 443000, China
中国 宜昌 宜昌市中心人民医院消化内科
A 21-year-old man presented to an outpatient clinic with an 8-month history of hematochezia, abdominal pain, tiredness, and weight loss. His abdomen was soft, with mild left lower quadrant abdominal tenderness and active bowel sounds. Laboratory evaluation revealed a hemoglobin level of 10.4 g per deciliter (normal range, 13.5 to 17.5).
Computed tomography of the abdomen revealed thickened wall of colon sigmoideum and rectum (Figure 1A). The colonoscopy showed congestion, edema and ulcer in the same location (Figure 1B), and mucosal biopsy by colonoscopy suggested that submucosal abscess was formed and presented as fissuring ulcers. T-SPOT.TB assay was negative. Two weeks later, the painful and rapidly progressive ulcerative lesions involving the left ankle joint was shown sequentially accompanied by red swollen (the 1st day; Figure 1C), deep ulcers (the 3rd day; Figure 1D), and necrosis (the 5th day; Figure 1E).
The physical examination showed skin ulcerations with both an irregular purple and a purulent base edge. The histopathological detection of an incisional biopsy sample separated from the ankle lesion revealed both superficial dermal and epidermal necrosis with leukocytoclastic vasculitis, an underlying mixed inflammatory-cell infiltrate and abscess formation. Direct microbiologic detection and cultures were negative for bacterial and fungal pathogens.
A diagnosis of pyoderma gangrenosum (PG) in ulcerative colitis was made. PG is an inflammatory skin disease with characteristics of rarity, chronicity and destructiveness, in which a painful nodule or pustule breaks down to generate a progressive and expansive ulcer with a undermined, tender and raised border (1-3). PG is usually related to systemic proinflammatory states, most particularly inﬂammatory bowel disease (4,5). Treatment can be extremely challenging, usually involving different kinds of immunosuppressive therapies (6,7).
In this patient, the debridement was given. Treatment with sulfasalazine was initiated, and 2 weeks later, methylprednisolone therapy was started. Four weeks later, dermatoplasty was performed. The cutaneous ulcers had diminished substantially, with residual superficial atrophic scars on the 7th day after the operation (Figure 1F). He was discharged home with synchronous resolution of hematochezia and abdominal pain symptoms, as well as with outpatient follow-up.